Min Li, Ph.D.

Our lab has been interested in studying cell surface molecules that mediate signal transduction in the nervous system. One area of our research focuses on the molecular and cellular mechanisms by which potassium channels are assembled and regulated. The native potassium channel complex contains pore-forming subunits, modulatory auxiliary subunits and posttranslational enzymes (e.g.., kinases and phosphotases). The combinatorial and regulatory assembly of these diverse proteins has been implicated in neuronal plasticity. We also identified and characterize novel compounds that either inhibit or activate potassium channels. Investigation of these chemicals may provide leads for therapeutics. Our long term goal is to understand the macromolecular organization and regulatory network of native ion channel complexes.